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“Our purpose is to be familiar with female reproductive getting older, and why fertility speedily declines setting up inside the mid-30s,” suggests Satoshi Namekawa, a professor of Microbiology and Molecular Genetics, in whose lab Munakata functions.
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The DNA inside a human oocyte encompasses some fifteen million nucleosomes — wrapping 2 times around each one — forming an structured structure named chromatin.
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Namekawa thinks that in human oocytes, modifications in here these designs could disrupt the sensitive choreography of genes staying turned on and off at the appropriate times — leaving them unprepared for fertilization or development into healthier embryos. Improvements in chromatin composition being an oocyte ages may also effects just how that chromosomes segregate through cell division.
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